pentobarbital will decrease the level or effect of lumacaftor/ivacaftor by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.pentobarbital will minimize the extent or impact of amlodipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.pentobarbital decreases levels of amphotericin B deo